Nimesulide

Category: Science / Pharmacology

  • Nimesulide is a non-steroidal anti-inflammatory drug (NSAID).
  • It has analgesic and antipyretic properties.
  • It acts primarily through inhibition of cyclooxygenase (COX) pathways, with relative preference for COX-2.
  • It has been associated with concerns regarding liver toxicity, which has led to restrictions on its use in several countries.
  • In India, its use is subject to regulatory restrictions, particularly concerning paediatric formulations.
  • UPSC questions may connect nimesulide with the broader issue of drug safety and pharmaceutical regulation.

Prelims Pointers: Drug class → NSAID | Uses → Pain + fever/inflammation | Major safety concern → Hepatotoxicity.